Anthony Davis and LeBron James starred as the Lakers led the Rockets 110-100 to take the lead in the Western Conference semifinals.
Davis scored a double-double and James finished an assist before a triple-double to help the top Lakers take a 3-1 lead in the best-of-seven NBA playoff series.
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Davis put on 29 points and 12 rebounds in Game 4 at Walt Disney World Resort on Thursday, while James recorded 16 points, 15 rebounds and nine assists.
The Lakers led by as much as 23 points in the middle of the fourth quarter and looked for a win before the Rockets bounced back.
Houston, who hit a 3-1 deficit in the second round of the 2015 playoffs, put together an 18-2 run against 103-96, but the Lakers held their own in the Orlando bubble.
Russell Westbrook led the Rockets with 25 points. All-Star teammate James Harden contributed 21 points.
Game 5 between the Lakers and Rockets takes place on Saturday.